apelin receptor (apj) — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T7656	Apelin-13
	Apelin-13 is a 13-amino acid peptide sequence found in the central and peripheral nervous system that is an endogenous ligand for the G protein-coupled receptor angiotensin II protein J (APJ), with an EC50 value of 0.37 ...
T7847	Apelin-13 triTFA(217082-58-1(free base))		Others
	Apelin-13 triTFA is the endogenous ligand of the APJ receptor, activating this G protein-coupled receptor with an EC50 value of 0.37 nM.		Others
TP1260	[Pyr1]-Apelin-13	[pGlu1]-Apelin-13	Apelin receptor
	[Pyr1]-Apelin-13 ([pGlu1]-Apelin-13) is a potent and selective endogenous Apelin receptor (APJ) agonist.		Apelin receptor
T39823L	Apelin-12 acetate	Apelin-12 acetate (229961-08-4 Free base)	Apelin receptor , p38 MAPK , JNK
	Apelin-12 acetate possesses a high affinity to orphan receptor APJ receptor. Apelin-12 acetate inhibits the JNK and p38 MAPK signaling pathway of the apoptosis-related MAPKs family, thus offering protection to neurons.		Apelin receptor , p38 MAPK , JNK
T10843	CMF019		Apelin receptor
	CMF019 is a potent agonist of the Apelin receptor (APJ) with G protein bias. CMF019 binds to APJ (pKis: 8.58, 8.49, and 8.71 for the human, rat, and mouse).		Apelin receptor
T63669	APJ receptor agonist 6
	APJ receptor agonist 6 is a potent agonist of the APJ (apelin receptor) (Ki: 0.059 μM). (EC50: 6.22 μM).
T10346	Apelin agonist 1		Others
	Apelin agonist 1 is an oral selective apelin agonist AM-2995, an agonist of the APJ (APLNR, angiotensin receptor like-1) receptor. It may be used in the treatment of cardiovascular conditions.		Others
T75785	Apelin-17(human, bovine) TFA
	Apelin-17(human, bovine) TFA is an endogenous agonist of the orphan G protein-coupled receptor APJ. This compound demonstrates affinity for human APJ receptors on HEK 293 cells, evidenced by a pIC50 value of 9.02. Additi...
T75783	Apelin-36(human) TFA
	Apelin-36(human) TFA, an endogenous agonist of the orphan G protein-coupled receptor APJ, exhibits a potent EC50 of 20 nM and high affinity (pIC5 50 = 8.61) for human APJ receptors in HEK 293 cells. It is involved in sig...
T63153	APJ receptor agonist 5
	APJ receptor agonist 5 (compound 3) is a potent and orally active apelin receptor (APJ) agonist (EC 50:0.4 nM). APJ receptor agonist 5 has excellent pharmacokinetic profiles in rodent models of heart failure (HF) and an ...
TP2001	MM 54
	Potent apelin receptor antagonist (Ki = 82 nM; IC50 = 93 nM). Antagonizes the inhibitory affect of [Pyr1]-Apelin-13 on forskolin-induced cAMP accumulation in CHO-K1-APJ cells. Recuces tumor expansion and lengthens surviv...
T75784	Apelin-36(rat, mouse) TFA
	Apelin-36(rat, mouse) TFA, an endogenous agonist for the orphan G protein-coupled receptor APJ, exhibits a strong affinity for APJ receptors with an IC 50 of 5.4 nM and effectively inhibits cAMP production with an EC 50 ...
T64305	APJ receptor agonist 7
	APJ receptor agonist 7 (compound 37) is an orally active APJ (apelin receptor) agonist (Ki: 0.059 μM). arrestin (EC50: 0.063 μM).
T39823	Apelin-12
	Apelin-12 is a highly potent C-terminal fragment of a polypeptide that exhibits a strong affinity towards the orphan receptor APJ. It plays a role in maintaining body fluid balance and regulating feeding control in the c...
T39813	APJ receptor agonist 1
	APJ receptor agonist 1, a potent biphenyl acid derivative, acts as an agonist (EC50 of 0.093 nM and 0.12 nM for human and rat APJ receptors, respectively) for the APJ receptor (APJ-R). It exhibits significant in vitro po...
T39587	APJ receptor agonist 4
	APJ Receptor Agonist 4 is a potent, orally active apelin receptor (APJ) agonist, demonstrating an EC50 of 0.06 nM and a Ki of 0.07 nM. It exhibits excellent pharmacokinetic profiles in rodent heart failure (HF) models an...
TP1923	Elabela(19-32)	ELA-14 (human)
	Potent apelin (APJ) receptor agonist (Ki = 0.93 nM). Bioactive fragment of ELA-32. Activates Gαi1 pathway and β-arrestin-2 recruitment. Reduces arterial pressure in rat hearts. Active in vivo.
TP1424	Apelin-13 TFA (217082-58-1 free base)	Apelin-13 TFA
	Apelin-13 is an endogenous ligand of APJ receptor, and the EC 50 value of activated G protein coupled receptor is 0.37 nM.
T76044	Elabela(19-32) TFA
	Elabela(19-32) TFA, an effective fragment of ELABELA (ELA), selectively engages with the apelin receptor (APJ). This compound initiates G αi1 and β-arrestin-2 signaling, demonstrating EC50 values of 8.6 nM and 166 nM, re...